| Contact Information: |
| Phone: (603) 650-7903 |
| Fax: (603) 650-8030 |
| Email: not given |
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| Institution Affiliations: |
| Section Chief, General Surgery |
| Associate Professor of Surgery |
| Department of: SURGERY |
| Section: General Surgery |
| Specialty: Surgical Oncology |
| Joined Staff: 1993 |
| Cancer Center Membership: |
| Clinical Interests: |
| Parathyroid Disease |
| Surgical Oncology |
| Immunotherapy for Colon and Rectal Cancer |
| Thyroid Surgery |
| Melanoma Surgery |
| Sarcoma Surgery |
| Liver Surgery |
| Pancreatic Surgery |
| Breast Surgery: Sentinel Node Excisions |
| Breast Surgery:Skin Sparing Mastectomies |
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| Board Certified: |
| Surgical Oncology |
| Surgery 1994 |
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| Harvard Medical School, Boston, MA 1985 |
| New England Deaconess Hospital, Boston, MA, (Surgery) 1985-88 |
| New England Deaconess Hospital, Boston, MA, (Surgery) 1990-92 |
| National Cancer Institute, National Institutes of Health, Bethesda, MD, (Surgical Oncology) 1988-90 |
| Biography: |
| Dr. Barth received an A.B. in Biochemical Sciences from Princeton in 1981, and an M.D. from Harvard Medical School in 1985. During the middle of his surgical residency at the New England Deaconess Hospital he spent 2.5 years in the laboratory of Dr. Steven Rosenberg at the National Cancer Institute. Dr. Barth joined the faculty of Dartmouth Medical School in 1993. |
| Research Interests: |
| Dr. Barth's lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines. |
| Selected Publications: |
| Mackey M, Gunn J, Ting P, Kikutani H, Dranoff G, Noelle R and Barth RJ. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154. Cancer Research 1997, 57:2569-74. |
| Mackey M, Noelle R, Barth RJ. The role of CD40/CD154 interactions in the priming, differentiation and effector function of helper and cytolytic T cells. J Leukocyte Biology 1998, 63: 418-28. |
| M, Gunn J, Maliszewski C, Kikutani H, Noelle R, Barth RJ. Dendritic cells require maturation via CD40 in vivo to generate protective anti-tumor immunity, J. Immunology 1998, 161:2094-8. |
| Schwaab T, Weiss J, Schned A, Barth RJ. Influence of the cytokine microenvironment on dendritic cell infiltration in colon cancer, Cancer 2000, in press. |
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Mailing Address:
Norris Cotton Cancer Center
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
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